Neutering, disease and golden retrievers

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Neutering, disease and golden retrievers

Post by buglad » Fri, 08 Mar 2013 21:26:23



Neutering Dogs: Effects on Joint Disorders and Cancers in Golden Retrievers
Full text available
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.00...
"In contrast to European countries, the overwhelming majority of dogs in
the U.S. are neutered (including spaying), usually done before one year
of age. Given the importance of gonadal hormones in growth and
development, this cultural contrast invites an analysis of the multiple
organ systems that may be adversely affected by neutering. Using a
single breed-specific dataset, the objective was to examine the
variables of gender and age at the time of neutering versus leaving dogs
gonadally intact, on all diseases occurring with sufficient frequency
for statistical analyses. Given its popularity and vulnerability to
various cancers and joint disorders, the Golden Retriever was chosen for
this study. Veterinary hospital records of 759 client-owned, intact and
neutered female and male dogs, 18 years old, were examined for
diagnoses of hip dysplasia (HD), cranial cruciate ligament tear (CCL),
lymphosarcoma (LSA), hemangiosarcoma (HSA), and mast cell tumor (MCT).
Patients were classified as intact, or neutered early (<12 mo) or late
(12 mo). Statistical analyses involved survival analyses and incidence
rate comparisons. Outcomes at the 5 percent level of significance are
reported. Of early-neutered males, 10 percent were diagnosed with HD,
double the occurrence in intact males. There were no cases of CCL
diagnosed in intact males or females, but in early-neutered males and
females the occurrences were 5 percent and 8 percent, respectively.
Almost 10 percent of early-neutered males were diagnosed with LSA, 3
times more than intact males. The percentage of HSA cases in
late-neutered females (about 8 percent) was 4 times more than intact and
early-neutered females. There were no cases of MCT in intact females,
but the occurrence was nearly 6 percent in late-neutered females. The
results have health implications for Golden Retriever companion and
service dogs, and for oncologists using dogs as models of cancers that
occur in humans."

buglady
takeout the dog before replying